Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment

BACKGROUND: Defective copper regulation is implicated as a causative mechanism of organ damage in diabetes. Treatment with trientine, a divalent-copper-selective chelator, improves arterial and renal structure/function in diabetes, wherein it also ameliorates left-ventricular (LV) hypertrophy. Howev...

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Autors principals: Lu, Jun, Pontré, Beau, Pickup, Stephen, Choong, Soon Y, Li, Mingming, Xu, Hong, Gamble, Gregory D, Phillips, Anthony RJ, Cowan, Brett R, Young, Alistair A, Cooper, Garth JS
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602174/
https://ncbi.nlm.nih.gov/pubmed/23368770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-12-28
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