The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication

BACKGROUND: HIV-1 translation is modulated by the activation of the interferon (IFN)-inducible Protein Kinase RNA-activated (PKR). PKR phosphorylates its downstream targets, including the alpha subunit of the eukaryotic translation Initiation Factor 2 (eIF2α), which decreases viral replication. The...

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Detalhes bibliográficos
Main Authors: Clerzius, Guerline, Shaw, Eileen, Daher, Aïcha, Burugu, Samantha, Gélinas, Jean-François, Ear, Thornin, Sinck, Lucile, Routy, Jean-Pierre, Mouland, Andrew J, Patel, Rekha C, Gatignol, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848765/
https://ncbi.nlm.nih.gov/pubmed/24020926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-96
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