Partial loss of Smad signaling during in vitro progression of HPV16-immortalized human keratinocytes

BACKGROUND: Disruption of the transforming growth factor-beta (TGF-β) signaling pathway is observed in many cancers, including cervical cancer, resulting in TGF-β resistance. While normal human keratinocytes (HKc) and human papillomavirus type 16-immortalized HKc (HKc/HPV16) are sensitive to the gro...

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Autores principales: Altomare, Diego, Velidandla, Rupa, Pirisi, Lucia, Creek, Kim E
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848426/
https://ncbi.nlm.nih.gov/pubmed/24047375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-424
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