Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis

Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disease characterized by severe psychomotor retardation, achlorhydria, and ophthalmological abnormalities. Cells from several tissues in MLIV patients accumulate large vacuoles that are presumed to be lysosomes, but whose exact...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Treusch, Sebastian, Knuth, Sarah, Slaugenhaupt, Susan A., Goldin, Ehud, Grant, Barth D., Fares, Hanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384773/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15070744/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400709101
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