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Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis

BACKGROUND: CUP-5 is a Transient Receptor Potential protein in C. elegans that is the orthologue of mammalian TRPML1. Loss of TRPML1 results in the lysosomal storage disorder Mucolipidosis type IV. Loss of CUP-5 results in embryonic lethality and the accumulation of enlarged yolk granules in develop...

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Detaylı Bibliyografya
Asıl Yazarlar: Campbell, Erin M, Fares, Hanna
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891664/
https://ncbi.nlm.nih.gov/pubmed/20540742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-11-40
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