Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis

Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disease characterized by severe psychomotor retardation, achlorhydria, and ophthalmological abnormalities. Cells from several tissues in MLIV patients accumulate large vacuoles that are presumed to be lysosomes, but whose exact...

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Bibliographic Details
Main Authors: Treusch, Sebastian, Knuth, Sarah, Slaugenhaupt, Susan A., Goldin, Ehud, Grant, Barth D., Fares, Hanna
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC384773/
https://ncbi.nlm.nih.gov/pubmed/15070744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400709101
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