Histone acetyltransferase PCAF Up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling

BACKGROUND: PCAF is an important intrinsic histone acetyltransferases. This study tried to establish the effect of PCAF on HCC cell apoptosis. METHOD: Both in vitro and in vivo experiments including IHC, DAPI staining, caspase 3/7 activity assay, BrdU assay, MTT assay, western immunoblotting and co-...

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Bibliografiske detaljer
Main Authors: Zheng, Xin, Gai, Xiaohong, Ding, Feihu, Lu, Zhongtang, Tu, Kangsheng, Yao, Yingmin, Liu, Qingguang
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847488/
https://ncbi.nlm.nih.gov/pubmed/23981651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-96
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