The dopamine D(1) receptor is expressed and facilitates relaxation in airway smooth muscle

BACKGROUND: Dopamine signaling is mediated by G(s) protein-coupled “D(1)-like” receptors (D(1) and D(5)) and G(i)-coupled “D(2)-like” receptors (D(2-4)). In asthmatic patients, inhaled dopamine induces bronchodilation. Although the G(i)-coupled dopamine D(2) receptor is expressed and sensitizes aden...

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Hlavní autoři: Mizuta, Kentaro, Zhang, Yi, Xu, Dingbang, Mizuta, Fumiko, D’Ovidio, Frank, Masaki, Eiji, Emala, Charles W
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847358/
https://ncbi.nlm.nih.gov/pubmed/24004608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-89
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