CD40-directed scFv-TRAIL fusion proteins induce CD40-restricted tumor cell death and activate dendritic cells

Targeted cancer therapy concepts often aim at the induction of adjuvant antitumor immunity or stimulation of tumor cell apoptosis. There is further evidence that combined application of immune stimulating and tumor apoptosis-inducing compounds elicits a synergistic antitumor effect. Here, we describ...

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Hlavní autoři: El-Mesery, M, Trebing, J, Schäfer, V, Weisenberger, D, Siegmund, D, Wajant, H
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847307/
https://ncbi.nlm.nih.gov/pubmed/24232092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.402
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