GRK2 blockade with βARKct is essential for cardiac β(2)-adrenergic receptor signaling towards increased contractility

BACKGROUND: β(1)- and β(2)–adrenergic receptors (ARs) play distinct roles in the heart, e.g. β(1)AR is pro-contractile and pro-apoptotic but β(2)AR anti-apoptotic and only weakly pro-contractile. G protein coupled receptor kinase (GRK)-2 desensitizes and opposes βAR pro-contractile signaling by phos...

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Bibliographische Detailangaben
Hauptverfasser: Salazar, Norma C, Vallejos, Ximena, Siryk, Ashley, Rengo, Giuseppe, Cannavo, Alessandro, Liccardo, Daniela, De Lucia, Claudio, Gao, Erhe, Leosco, Dario, Koch, Walter J, Lymperopoulos, Anastasios
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846709/
https://ncbi.nlm.nih.gov/pubmed/23984976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-64
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