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GRK2 blockade with βARKct is essential for cardiac β(2)-adrenergic receptor signaling towards increased contractility
BACKGROUND: β(1)- and β(2)–adrenergic receptors (ARs) play distinct roles in the heart, e.g. β(1)AR is pro-contractile and pro-apoptotic but β(2)AR anti-apoptotic and only weakly pro-contractile. G protein coupled receptor kinase (GRK)-2 desensitizes and opposes βAR pro-contractile signaling by phos...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3846709/ https://ncbi.nlm.nih.gov/pubmed/23984976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-64 |
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