Blockade of β-adrenoceptors restores the GRK2-mediated adrenal α(2)-adrenoceptor–catecholamine production axis in heart failure

BACKGROUND AND PURPOSE: Sympathetic nervous system (SNS) hyperactivity is characteristic of chronic heart failure (HF) and significantly worsens prognosis. The success of β-adrenoceptor antagonist (β-blockers) therapy in HF is primarily attributed to protection of the heart from the noxious effects...

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Bibliographic Details
Main Authors: Rengo, G, Lymperopoulos, A, Zincarelli, C, Femminella, GD, Liccardo, D, Pagano, G, de Lucia, C, Cannavo, A, Gargiulo, P, Ferrara, N, Perrone Filardi, P, Koch, WJ, Leosco, D
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2012
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448904/
https://ncbi.nlm.nih.gov/pubmed/22519418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01972.x
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