Fine mapping of V(D)J recombinase mediated rearrangements in human lymphoid malignancies

BACKGROUND: Lymphocytes achieve diversity in antigen recognition in part by rearranging genomic DNA at loci encoding antibodies and cell surface receptors. The process, termed V(D)J recombination, juxtaposes modular coding sequences for antigen binding. Erroneous recombination events causing chromos...

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Main Authors: Halper-Stromberg, Eitan, Steranka, Jared, Giraldo-Castillo, Nicolas, Fuller, Timothy, Desiderio, Stephen, Burns, Kathleen H
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846541/
https://ncbi.nlm.nih.gov/pubmed/23957733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-565
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