Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice

BACKGROUND & AIMS: While non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis combined with inflammation, the mechanisms triggering hepatic inflammation are unknown. In Ldlr(-/-) mice, we have previously shown that lysosomal cholesterol accumulation in Kupffer cells (KCs) c...

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Main Authors: Hendrikx, Tim, Bieghs, Veerle, Walenbergh, Sofie M. A., van Gorp, Patrick J., Verheyen, Fons, Jeurissen, Mike L. J., Steinbusch, Mandy M. F., Vaes, Nathalie, Binder, Christoph J., Koek, Ger H., Stienstra, Rinke, Netea, Mihai G., Hofker, Marten H., Shiri-Sverdlov, Ronit
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846469/
https://ncbi.nlm.nih.gov/pubmed/24312444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078792
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