Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice

BACKGROUND & AIMS: While non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis combined with inflammation, the mechanisms triggering hepatic inflammation are unknown. In Ldlr(-/-) mice, we have previously shown that lysosomal cholesterol accumulation in Kupffer cells (KCs) c...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hendrikx, Tim, Bieghs, Veerle, Walenbergh, Sofie M. A., van Gorp, Patrick J., Verheyen, Fons, Jeurissen, Mike L. J., Steinbusch, Mandy M. F., Vaes, Nathalie, Binder, Christoph J., Koek, Ger H., Stienstra, Rinke, Netea, Mihai G., Hofker, Marten H., Shiri-Sverdlov, Ronit
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846469/
https://ncbi.nlm.nih.gov/pubmed/24312444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078792
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