Internalization of Modified Lipids by CD36 and SR-A Leads to Hepatic Inflammation and Lysosomal Cholesterol Storage in Kupffer Cells

BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis and inflammation, which can further progress into fibrosis and cirrhosis. Recently, we demonstrated that combined deletion of the two main scavenger receptors, CD36 and macrophage scavenger receptor 1 (MSR1), w...

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Main Authors: Bieghs, Veerle, Verheyen, Fons, van Gorp, Patrick J., Hendrikx, Tim, Wouters, Kristiaan, Lütjohann, Dieter, Gijbels, Marion J. J., Febbraio, Maria, Binder, Christoph J., Hofker, Marten H., Shiri-Sverdlov, Ronit
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314620/
https://ncbi.nlm.nih.gov/pubmed/22470565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034378
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