Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice

BACKGROUND & AIMS: While non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis combined with inflammation, the mechanisms triggering hepatic inflammation are unknown. In Ldlr(-/-) mice, we have previously shown that lysosomal cholesterol accumulation in Kupffer cells (KCs) c...

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Detalhes bibliográficos
Main Authors: Hendrikx, Tim, Bieghs, Veerle, Walenbergh, Sofie M. A., van Gorp, Patrick J., Verheyen, Fons, Jeurissen, Mike L. J., Steinbusch, Mandy M. F., Vaes, Nathalie, Binder, Christoph J., Koek, Ger H., Stienstra, Rinke, Netea, Mihai G., Hofker, Marten H., Shiri-Sverdlov, Ronit
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846469/
https://ncbi.nlm.nih.gov/pubmed/24312444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078792
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