Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice

Activation of xenobiotic metabolism pathways has been linked to lifespan extension in different models of aging. However, the mechanisms underlying activation of xenobiotic genes remain largely unknown. Here we showed that although FXR mRNA levels do not change significantly, FXR (farnesoid X recept...

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Bibliografski detalji
Glavni autori: Jiang, Yanjun, Jin, Jingling, Iakova, Polina, Hernandez, Julio Cesar, Jawanmardi, Nicole, Sullivan, Emily, Guo, Grace L., Timchenko, Nikolai A., Darlington, Gretchen J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845407/
https://ncbi.nlm.nih.gov/pubmed/24007921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2013.08.003
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