Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice

Activation of xenobiotic metabolism pathways has been linked to lifespan extension in different models of aging. However, the mechanisms underlying activation of xenobiotic genes remain largely unknown. Here we showed that although FXR mRNA levels do not change significantly, FXR (farnesoid X recept...

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Detalhes bibliográficos
Main Authors: Jiang, Yanjun, Jin, Jingling, Iakova, Polina, Hernandez, Julio Cesar, Jawanmardi, Nicole, Sullivan, Emily, Guo, Grace L., Timchenko, Nikolai A., Darlington, Gretchen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845407/
https://ncbi.nlm.nih.gov/pubmed/24007921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2013.08.003
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