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ER Dysfunction and Protein Folding Stress in ALS

Amyotrophic lateral sclerosis (ALS) is the most frequent paralytic disease in adults. Most ALS cases are considered sporadic with no clear genetic component. The disruption of protein homeostasis due to chronic stress responses at the endoplasmic reticulum (ER) and the accumulation of abnormal prote...

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Autors principals: Matus, Soledad, Valenzuela, Vicente, Medinas, Danilo B., Hetz, Claudio
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845333/
https://ncbi.nlm.nih.gov/pubmed/24324498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/674751
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