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Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders

Prion-related disorders (PrDs) are caused by the accumulation of a misfolded and protease-resistant form of the cellular prion, leading to neuronal dysfunction and massive neuronal loss. In humans, PrDs have distinct etiologies including sporadic, infectious and familial forms, which present common...

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Bibliografski detalji
Glavni autori: Torres, Mauricio, Encina, Gonzalo, Soto, Claudi, Hetz, Claudio
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187882/
https://ncbi.nlm.nih.gov/pubmed/21980554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cib.4.3.15019
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