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Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders

Prion-related disorders (PrDs) are caused by the accumulation of a misfolded and protease-resistant form of the cellular prion, leading to neuronal dysfunction and massive neuronal loss. In humans, PrDs have distinct etiologies including sporadic, infectious and familial forms, which present common...

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Detalhes bibliográficos
Main Authors: Torres, Mauricio, Encina, Gonzalo, Soto, Claudi, Hetz, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187882/
https://ncbi.nlm.nih.gov/pubmed/21980554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cib.4.3.15019
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