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Not-in-trial simulation I: Bridging cardiovascular risk from clinical trials to real-life conditions
AIMS: The assessment of heart rate-corrected QT (QTc) interval prolongation relies on the evidence of drug effects in healthy subjects. This study demonstrates the relevance of pharmacokinetic–pharmacodynamic (PKPD) relationships to characterize drug-induced QTc interval prolongation and explore the...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Science Inc
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3845320/ https://ncbi.nlm.nih.gov/pubmed/23617533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12151 |
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