Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy

The motor neuron (MN) degenerative disease, spinal muscular atrophy (SMA) is caused by deficiency of SMN (survival motor neuron), a ubiquitous and indispensable protein essential for biogenesis of snRNPs, key components of pre-mRNA processing. However, SMA’s hallmark MN pathology, including neuromus...

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Zhenxi, Pinto, Anna Maria, Wan, Lili, Wang, Wei, Berg, Michael G., Oliva, Isabela, Singh, Larry N., Dengler, Christopher, Wei, Zhi, Dreyfuss, Gideon
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845193/
https://ncbi.nlm.nih.gov/pubmed/24191055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319280110
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