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Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy

The motor neuron (MN) degenerative disease, spinal muscular atrophy (SMA) is caused by deficiency of SMN (survival motor neuron), a ubiquitous and indispensable protein essential for biogenesis of snRNPs, key components of pre-mRNA processing. However, SMA’s hallmark MN pathology, including neuromus...

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Autors principals: Zhang, Zhenxi, Pinto, Anna Maria, Wan, Lili, Wang, Wei, Berg, Michael G., Oliva, Isabela, Singh, Larry N., Dengler, Christopher, Wei, Zhi, Dreyfuss, Gideon
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845193/
https://ncbi.nlm.nih.gov/pubmed/24191055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319280110
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