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The Interface between Extracellular and Transmembrane Domains of Homomeric Cys-Loop Receptors Governs Open-Channel Lifetime and Rate of Desensitization

The lifetimes of activated postsynaptic receptor channels contribute to the efficiency of synaptic transmission. Here we show that structural differences within the interface dividing extracellular and transmembrane domains of homomeric α7 and 5-HT(3A) receptors account for the large differences in...

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Bibliografiske detaljer
Main Authors: Bouzat, Cecilia, Bartos, Mariana, Corradi, Jeremías, Sine, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844810/
https://ncbi.nlm.nih.gov/pubmed/18667613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0448-08.2008
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