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Single-Channel Kinetic Analysis for Activation and Desensitization of Homomeric 5-HT(3)A Receptors
The 5-HT(3)A receptor is a member of the Cys-loop family of ligand-gated ion channels. To perform kinetic analysis, we mutated the 5-HT3A subunit to obtain a high-conductance form so that single-channel currents can be detected. At all 5-HT concentrations (>0.1 μM), channel activity appears as op...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749742/ https://ncbi.nlm.nih.gov/pubmed/19720021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.06.018 |
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