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Retinoic Acid Attenuates β-Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model

Recent studies have revealed that disruption of vitamin A signaling observed in Alzheimer's disease (AD) leads to β-amyloid (Aβ) accumulation and memory deficits in rodents. The aim of the present study was to evaluate the therapeutic effect of all-trans retinoic acid (ATRA), an active metaboli...

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Autori principali: Ding, Yun, Qiao, Aimin, Wang, Ziqing, Goodwin, J. Shawn, Lee, Eun-Sook, Block, Michelle L., Allsbrook, Matthew, McDonald, Michael P., Fan, Guo-Huang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844785/
https://ncbi.nlm.nih.gov/pubmed/18987198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3153-08.2008
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