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Skeletal Muscle-Specific CPT1 Deficiency Elevates Lipotoxic Intermediates but Preserves Insulin Sensitivity

Objective. By specific knockout of carnitine palmitoyl transferase 1b (CPT1b) in skeletal muscles, we explored the effect of CPT1b deficiency on lipids and insulin sensitivity. Methods. Mice with specific knockout of CPT1b in skeletal muscles (CPT1b M−/−) were used for the experiment group, with lit...

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Detalhes bibliográficos
Main Authors: Shi, Wanchun, Hu, Siping, Wang, Wenhua, Zhou, Xiaohui, Qiu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844227/
https://ncbi.nlm.nih.gov/pubmed/24319696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/163062
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