Structure of the Toxoplasma gondii ROP18 Kinase Domain Reveals a Second Ligand Binding Pocket Required for Acute Virulence

At least a third of the human population is infected with the intracellular parasite Toxoplasma gondii, which contributes significantly to the disease burden in immunocompromised and neutropenic hosts and causes serious congenital complications when vertically transmitted to the fetus. Genetic analy...

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Détails bibliographiques
Auteurs principaux: Lim, Daniel, Gold, Daniel A., Julien, Lindsay, Rosowski, Emily E., Niedelman, Wendy, Yaffe, Michael B., Saeij, Jeroen P. J.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843107/
https://ncbi.nlm.nih.gov/pubmed/24129568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523266
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