Structure of the Toxoplasma gondii ROP18 Kinase Domain Reveals a Second Ligand Binding Pocket Required for Acute Virulence

At least a third of the human population is infected with the intracellular parasite Toxoplasma gondii, which contributes significantly to the disease burden in immunocompromised and neutropenic hosts and causes serious congenital complications when vertically transmitted to the fetus. Genetic analy...

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Detalhes bibliográficos
Main Authors: Lim, Daniel, Gold, Daniel A., Julien, Lindsay, Rosowski, Emily E., Niedelman, Wendy, Yaffe, Michael B., Saeij, Jeroen P. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843107/
https://ncbi.nlm.nih.gov/pubmed/24129568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523266
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