Multimodal Mechanism of Action for the Cdc34 Acidic Loop: A CASE STUDY FOR WHY UBIQUITIN-CONJUGATING ENZYMES HAVE LOOPS AND TAILS

Together with ubiquitin ligases (E3), ubiquitin-conjugating enzymes (E2) are charged with the essential task of synthesizing ubiquitin chains onto protein substrates. Some 75% of the known E2s in the human proteome contain unique insertions in their primary sequences, yet it is largely unclear what...

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Detalhes bibliográficos
Main Authors: Ziemba, Amy, Hill, Spencer, Sandoval, Daniella, Webb, Kristofor, Bennett, Eric J., Kleiger, Gary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843100/
https://ncbi.nlm.nih.gov/pubmed/24129577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.509190
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