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Elastin Degradation by Cathepsin V Requires Two Exosites

Cathepsin V is a highly effective elastase and has been implicated in physiological and pathological extracellular matrix degradation. However, its mechanism of action remains elusive. Whereas human cathepsin V exhibits a potent elastolytic activity, the structurally homologous cathepsin L, which sh...

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Hlavní autoři: Du, Xin, Chen, Nelson L. H., Wong, Andre, Craik, Charles S., Brömme, Dieter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843099/
https://ncbi.nlm.nih.gov/pubmed/24121514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510008
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