NRH:Quinone Oxidoreductase 2 (NQO2) Protein Competes with the 20 S Proteasome to Stabilize Transcription Factor CCAAT Enhancer-binding Protein α (C/EBPα), Leading to Protection against γ Radiation-induced Myeloproliferative Disease

NRH:quinone oxidoreductase 2 (NQO2) is a flavoprotein that protects cells against radiation and chemical-induced oxidative stress. Disruption of the NQO2 gene in mice leads to γ radiation-induced myeloproliferative diseases. In this report, we showed that the 20 S proteasome and NQO2 both interact w...

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Hlavní autoři: Xu, Junkang, Patrick, Brad Allen, Jaiswal, Anil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843093/
https://ncbi.nlm.nih.gov/pubmed/24142791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.495580
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