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NAD(P)H:quinone Oxidoreductase 1 (NQO1) Competes with 20S Proteasome for Binding with C/EBPα Leading to Its Stabilization and Protection against Radiation-induced Myeloproliferative Disease
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that protects cells against radiation and chemical-induced oxidative stress. Disruption of NQO1 gene in mice leads to increased susceptibility to myeloproliferative disease. In this report, we demonstrate that NQO1 controls the stability of m...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516712/ https://ncbi.nlm.nih.gov/pubmed/23086932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.387738 |
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