Histone Lysine-specific Demethylase 1 (LSD1) Protein Is Involved in Sal-like Protein 4 (SALL4)-mediated Transcriptional Repression in Hematopoietic Stem Cells

The stem cell protein SALL4 plays a critical role in hematopoiesis by regulating the cell fate. In primitive hematopoietic precursors, it activates or represses important genes via recruitment of various epigenetic factors such as DNA methyltransferases, and histone deacylases. Here, we demonstrate...

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Autori principali: Liu, Li, Souto, Joseph, Liao, Wenbin, Jiang, Yongping, Li, Yangqiu, Nishinakamura, Ryuichi, Huang, Suming, Rosengart, Todd, Yang, Vincent W., Schuster, Michael, Ma, Yupo, Yang, Jianchang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843083/
https://ncbi.nlm.nih.gov/pubmed/24163373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.506568
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