Identifying Key Amino Acid Residues That Affect α-Conotoxin AuIB Inhibition of α3β4 Nicotinic Acetylcholine Receptors

α-Conotoxin AuIB is a selective α3β4 nicotinic acetylcholine receptor (nAChR) subtype inhibitor. Its analgesic properties are believed to result from it activating GABA(B) receptors and subsequently inhibiting Ca(V)2.2 voltage-gated calcium channels. The structural determinants that mediate divergin...

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Detalhes bibliográficos
Main Authors: Grishin, Anton A., Cuny, Hartmut, Hung, Andrew, Clark, Richard J., Brust, Andreas, Akondi, Kalyana, Alewood, Paul F., Craik, David J., Adams, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843058/
https://ncbi.nlm.nih.gov/pubmed/24100032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512582
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