Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease

Oxidative stress contributes to neurodegeneration in Huntington's disease (HD). However, the origins of oxidative stress in HD remain unclear. Studies in HD transgenic models suggest involvement of mitochondrial dysfunction, which would lead to overproduction of reactive oxygen species (ROS). I...

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Main Authors: Li, Xueyi, Valencia, Antonio, Sapp, Ellen, Masso, Nicholas, Alexander, Jonathan, Reeves, Patrick, Kegel, Kimberly B., Aronin, Neil, DiFiglia, Marian
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842456/
https://ncbi.nlm.nih.gov/pubmed/20357106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5865-09.2010
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