Novel Functional Assay for Spindle-Assembly Checkpoint by Cyclin-Dependent Kinase Activity to Predict Taxane Chemosensitivity in Breast Tumor Patient

Taxanes are among the drugs most commonly used for preoperative chemotherapy for breast cancer. Taxanes induce mitotic arrest and subsequent apoptosis. The spindle-assembly checkpoint (SAC) is known to be activated during mitosis, along with cyclin-dependent kinase-1 (CDK1), and is required for taxa...

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Detalhes bibliográficos
Main Authors: Torikoshi, Yasuhiro, Gohda, Keigo, Davis, Michelle L., Symmans, W. Fraser, Pusztai, Lajos, Kazansky, Anna, Nakayama, Satoshi, Yoshida, Tomokazu, Matsushima, Tomoko, Hortobagyi, Gabriel N., Ishihara, Hideki, Kim, Seung Jin, Noguchi, Shinzaburo, Ueno, Naoto T.
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2013
Assuntos:
Short Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842438/
https://ncbi.nlm.nih.gov/pubmed/24312139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.6248
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