Novel Functional Assay for Spindle-Assembly Checkpoint by Cyclin-Dependent Kinase Activity to Predict Taxane Chemosensitivity in Breast Tumor Patient

Taxanes are among the drugs most commonly used for preoperative chemotherapy for breast cancer. Taxanes induce mitotic arrest and subsequent apoptosis. The spindle-assembly checkpoint (SAC) is known to be activated during mitosis, along with cyclin-dependent kinase-1 (CDK1), and is required for taxa...

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Hlavní autoři: Torikoshi, Yasuhiro, Gohda, Keigo, Davis, Michelle L., Symmans, W. Fraser, Pusztai, Lajos, Kazansky, Anna, Nakayama, Satoshi, Yoshida, Tomokazu, Matsushima, Tomoko, Hortobagyi, Gabriel N., Ishihara, Hideki, Kim, Seung Jin, Noguchi, Shinzaburo, Ueno, Naoto T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2013
Témata:
Short Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842438/
https://ncbi.nlm.nih.gov/pubmed/24312139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.6248
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