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Smad2 and Smad4 regulate TGF-β-mediated Il9 gene expression via EZH2 displacement*
IL-9 is a pro-allergic cytokine produced by a newly proposed T helper cell subset T(H)9. T(H)9 cells can be generated by treatment of naïve T cells with TGF-β and IL-4 in vitro. But how TGF-β signaling regulates T(H)9 differentiation is still not clear. Here we demonstrate that Smad2 and Smad4, two...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3842015/ https://ncbi.nlm.nih.gov/pubmed/24108699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300433 |
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