Spontaneous Generation of Infectious Prion Disease in Transgenic Mice

We generated transgenic mice expressing bovine cellular prion protein (PrP(C)) with a leucine substitution at codon 113 (113L). This protein is homologous to human protein with mutation 102L, and its genetic link with Gerstmann–Sträussler–Scheinker syndrome has been established. This mutation in bov...

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Bibliographische Detailangaben
Hauptverfasser: Torres, Juan-María, Castilla, Joaquín, Pintado, Belén, Gutiérrez-Adan, Alfonso, Andréoletti, Olivier, Aguilar-Calvo, Patricia, Arroba, Ana-Isabel, Parra-Arrondo, Beatriz, Ferrer, Isidro, Manzanares, Jorge, Espinosa, Juan-Carlos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Centers for Disease Control and Prevention 2013
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840888/
https://ncbi.nlm.nih.gov/pubmed/24274622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3201/eid1912.130106
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