Degradation of cIAPs contributes to hepatocyte lipoapoptosis

Hepatocyte apoptosis is a hallmark of nonalcoholic steatohepatitis. We have previously observed that the saturated free fatty acids (FFAs) induce hepatocyte apoptosis in part via a death receptor 5 (DR5)-mediated signaling pathway. Cellular inhibitor of apoptosis protein 1 and 2 (cIAP-1 and cIAP-2)...

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Main Authors: Akazawa, Yuko, Guicciardi, Maria Eugenia, Cazanave, Sophie C., Bronk, Steven F., Werneburg, Nathan W., Kakisaka, Keisuke, Nakao, Kazuhiko, Gores, Gregory J.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
Teme:
Call for Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840239/
https://ncbi.nlm.nih.gov/pubmed/24008361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00111.2013
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