A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

Antibacterial drug development suffers from a paucity of targets whose inhibition kills replicating and nonreplicating bacteria. The latter include phenotypically dormant cells, known as persisters, which are tolerant to many antibiotics and often contribute to failure in the treatment of chronic in...

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Detalhes bibliográficos
Main Authors: Kim, Jee-Hyun, O’Brien, Kathryn M., Sharma, Ritu, Boshoff, Helena I. M., Rehren, German, Chakraborty, Sumit, Wallach, Joshua B., Monteleone, Mercedes, Wilson, Daniel J., Aldrich, Courtney C., Barry, Clifton E., Rhee, Kyu Y., Ehrt, Sabine, Schnappinger, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839782/
https://ncbi.nlm.nih.gov/pubmed/24191058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315860110
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