Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense

Mycobacterium tuberculosis (Mtb) must cope with exogenous oxidative stress imposed by the host. Unlike other antioxidant enzymes, Mtb’s thioredoxin reductase TrxB2 has been predicted to be essential not only to fight host defenses but also for in vitro growth. However, the specific physiological rol...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Lin, Kan, O'Brien, Kathryn M., Trujillo, Carolina, Wang, Ruojun, Wallach, Joshua B., Schnappinger, Dirk, Ehrt, Sabine
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889078/
https://ncbi.nlm.nih.gov/pubmed/27249779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005675
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