A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

Antibacterial drug development suffers from a paucity of targets whose inhibition kills replicating and nonreplicating bacteria. The latter include phenotypically dormant cells, known as persisters, which are tolerant to many antibiotics and often contribute to failure in the treatment of chronic in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kim, Jee-Hyun, O’Brien, Kathryn M., Sharma, Ritu, Boshoff, Helena I. M., Rehren, German, Chakraborty, Sumit, Wallach, Joshua B., Monteleone, Mercedes, Wilson, Daniel J., Aldrich, Courtney C., Barry, Clifton E., Rhee, Kyu Y., Ehrt, Sabine, Schnappinger, Dirk
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839782/
https://ncbi.nlm.nih.gov/pubmed/24191058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315860110
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