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Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain

Toll/IL-1R resistance (TIR) domain–containing adapter-inducing IFN-β (TRIF) is a Toll-like receptor (TLR) adapter that mediates MyD88-independent induction of type I interferons through activation of IFN regulatory factor 3 and NFκB. We have examined peptides derived from the TRIF TIR domain for abi...

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Detalles Bibliográficos
Main Authors: Piao, Wenji, Ru, Lisa W., Piepenbrink, Kurt H., Sundberg, Eric J., Vogel, Stefanie N., Toshchakov, Vladimir Y.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839745/
https://ncbi.nlm.nih.gov/pubmed/24194546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313575110
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