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Mimicry of High-Density Lipoprotein: Functional Peptide–Lipid Nanoparticles Based on Multivalent Peptide Constructs

We describe an approach for engineering peptide–lipid nanoparticles that function similarly to high-density lipoprotein (HDL). Branched, multivalent constructs, bearing multiple 23- or 16-amino-acid peptides, were designed, synthesized and combined with phospholipids to produce nanometer-scale disco...

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Detalhes bibliográficos
Main Authors: Zhao, Yannan, Imura, Tomohiro, Leman, Luke J., Curtiss, Linda K., Maryanoff, Bruce E., Ghadiri, M. Reza
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839580/
https://ncbi.nlm.nih.gov/pubmed/23978057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja404714a
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