Highly polarized Th17 cells induce EAE via a T-bet-independent mechanism

In the MOG(35-55) induced EAE model, autoreactive Th17 cells that accumulate in the central nervous system (CNS) acquire Th1 characteristics via a T-bet dependent mechanism. It remains to be determined whether Th17 plasticity and encephalitogenicity are causally related to each other. Here we show t...

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Bibliographic Details
Main Authors: Grifka-Walk, Heather M., Lalor, Stephen J., Segal, Benjamin M.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838449/
https://ncbi.nlm.nih.gov/pubmed/23878008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343723
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