Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects.

The essential eukaryotic pre-mRNA splicing factor U2AF (U2 small nuclear ribonucleoprotein auxiliary factor) is required to specify the 3' splice at an early step in spliceosome assembly. U2AF binds site-specifically to the intron polypyrimidine tract and recruits U2 small nuclear ribonucleoprotein...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Rudner, D Z, Kanaar, R, Breger, K S, Rio, D C
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1996
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38384/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816800/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.19.10333
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