Activation of the Endoplasmic Reticulum Calcium Sensor STIM1 and Store-Operated Calcium Entry by Rotavirus Requires NSP4 Viroporin Activity

Rotavirus nonstructural protein 4 (NSP4) induces dramatic changes in cellular calcium homeostasis. These include increased endoplasmic reticulum (ER) permeability, resulting in decreased ER calcium stores and activation of plasma membrane (PM) calcium influx channels, ultimately causing a 2- to 4-fo...

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Bibliografiske detaljer
Main Authors: Hyser, Joseph M., Utama, Budi, Crawford, Sue E., Broughman, James R., Estes, Mary K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838237/
https://ncbi.nlm.nih.gov/pubmed/24109210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02629-13
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