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The Nuclear-Cytoplasmic Shuttling of Virion Host Shutoff RNase Is Enabled by pU(L)47 and an Embedded Nuclear Export Signal and Defines the Sites of Degradation of AU-Rich and Stable Cellular mRNAs
The herpes simplex virus host shutoff RNase (VHS-RNase) is the major early block of host responses to infection. VHS-RNase is introduced into cells during infection and selectively degrades stable mRNAs made before infection and the normally short-lived AU-rich stress response mRNAs induced by senso...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3838220/ https://ncbi.nlm.nih.gov/pubmed/24109211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02603-13 |
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